Straight Lab

A Biochemistry Sub-site Tagline (if needed)

  • Dr. Paul Straight’s Lab
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Dr. Paul Straight’s Lab

  • image6369_square
    Representation of bacterial interactions from soil.
  • F1
    Induction of prodiginine production in Streptomyces lividans by Bacillus subtilis.
  • Motility
    Induction of motility in Bacillus subtilis by Streptomyces venezuelae.
  • IMS
    Image mass spectroscopy of specialized metabolites in Streptomyces sp. Mg1 and Bacillus subtilis.

The goal of this laboratory is to understand how microorganisms interact in complex communities. Specifically, we study how small molecules produced in a microbial community affect the growth, development and metabolic output of the organisms. We use a combination of microbiology, genetic, genomic, and biochemical approaches to dissect complex interspecies interactions. Currently, our research focuses on the interactions of the soil bacteria Bacillus subtilis and members of the genus Streptomyces, known for their prolific production of bioactive small molecules and development of aerial structures and spores.

Recent Publications

  1. Zhang, C, Straight, PD. Antibiotic discovery through microbial interactions. Curr Opin Microbiol. 2019;51 :64-71. doi: 10.1016/j.mib.2019.06.006. PubMed PMID:31344518 .
  2. Liu, Y, Kyle, S, Straight, PD. Antibiotic Stimulation of a Bacillus subtilis Migratory Response. mSphere. 2018;3 (1):. doi: 10.1128/mSphere.00586-17. PubMed PMID:29507890 PubMed Central PMC5821984.
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