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Straight Lab

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Kalyani Josyula

I acquired my PhD from Indian Institute of Science in Biochemistry and joined department of Biochemistry at Purdue University as a postdoctoral fellow. My research interest always revolved around specialized metabolism and competitive fitness. I am interested in understanding the underlying mechanisms that influence the metabolism of bacteria to elicit certain behaviors. Streptomyces sp. Mg1 produces Linearmycins which result in lysis of proximal Bacillus subtilis when co-cultured together. We also found out that these linearmycins are present in the extracellular vesicles secreted by the Streptomyces. We hypothesize that the production of the exracellular vesicles is related to the biosynthesis of Linearmycins. I am working on localizing the biosynthetic enzymes from linearmycin BGC and observe the effect on membrane stability. I am also interested in isolation and identification of unknown compounds from Streptomyces venezuelae that can trigger mobility response in Bacillus subtilis.

 

 

 

 

Recent Publications

  1. LaBonte, S, Liu, Y, Powers, M, De Ford, E, Straight, PD. Chloramphenicol-mobilized Bacillus subtilis transiently expresses resistance to multiple antibiotics, including the glycopeptides phleomycin and bleomycin. bioRxiv. 2025; :. doi: 10.1101/2025.01.13.632840. PubMed PMID:39868268 PubMed Central PMC11761127.
  2. Straight, PJ, Gignac, PM, Kuenzel, WJ. A histological and diceCT-derived 3D reconstruction of the avian visual thalamofugal pathway. Sci Rep. 2024;14 (1):8447. doi: 10.1038/s41598-024-58788-z. PubMed PMID:38600121 PubMed Central PMC11006926.
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